Klebsiella pneumoniae-Derived Extracellular Vesicles Impair Endothelial Function by Inhibiting SIRT1 Academic Background Hypertension is a global health issue with a complex pathogenesis involving multiple factors. In recent years, the role of gut microbiota in hypertension has garnered significant attention. Studies have shown that dysbiosis of th...

Staphylococcus Aureus Vesicles Impair Cutaneous Wound Healing Through p38 MAPK-MerTK Cleavage-Mediated Inhibition of Macrophage Efferocytosis Background Introduction Staphylococcus aureus (S. aureus) is one of the primary pathogens causing chronic wound infections, particularly in diabetic patients, with an infection rate as high as 65%. One of the...

Report on a Study of the Dynamics of Carriage, Acquisition, and Transmission of ESBL-Producing E. coli (ESBL-EC) in Non-ICU Hospital Wards Over Two Years Antimicrobial resistance is an increasingly significant global public health issue, with the rapid dissemination of extended-spectrum beta-lactamase-producing (ESBL) Enterobacterales, such as Kleb...

Revisiting Mutational Resistance to Ampicillin and Cefotaxime in Haemophilus influenzae Background and Motivation for the Study Haemophilus influenzae is an opportunistic bacterial pathogen that can cause severe respiratory tract infections and invasive infections such as septicemia and meningitis, particularly in infants, the elderly, and immunoco...

Report on the Research Paper: Comprehensive Pathogen Identification and Antimicrobial Resistance Prediction from Positive Blood Cultures Using Nanopore Sequencing Technology Academic Context Bloodstream infections (BSIs) are severe clinical conditions typically diagnosed through positive blood culture results and systemic signs of infection. BSIs c...

Genomic Surveillance of Multidrug-Resistant Organisms Based on Long-Read Sequencing Research Background Multidrug-resistant organisms (MDROs) are a significant global public health threat. These organisms exhibit resistance to multiple antibiotics, making infections challenging to treat and increasing healthcare costs. To effectively monitor and co...

Research Background and Motivation Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a global health issue infecting and killing millions annually. Despite advances in TB diagnosis and treatment, the immune evasion strategies employed by Mtb remain a critical reason for its prolonged survival in the host, leading to chronic infectio...

Summary of the Academic Paper Report on “Century-Old Herbarium Specimen Provides Insights Into Pierce’s Disease of Grapevines Emergence in the Americas” Introduction Pierce’s Disease (PD) of grapevines, caused by the bacterial subspecies Xylella fastidiosa subsp. fastidiosa (Xff), poses a severe threat to the viticulture industry. However, its geog...

Comparative Analysis of Recombinant Quadrivalent Influenza Vaccine and Standard Egg-Based Quadrivalent Influenza Vaccine in Nursing Home Residents: A Cluster Randomized Trial Academic Background Influenza is among the primary respiratory pathogens causing morbidity and mortality among the elderly worldwide, particularly in nursing home residents wh...

Academic Background Tubercular Uveitis (TBU) is an ocular condition caused by Mycobacterium tuberculosis infection or immune-mediated inflammation. While tuberculosis (TB) remains a major global public health issue, the diagnosis and treatment of TBU continue to pose significant challenges. TBU presents a wide range of clinical manifestations, with...