Long-term Intravenous Anti-CD20 Antibody Therapy Assessment in a French Multiple Sclerosis Cohort Background and Research Motivation Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system, leading to varying degrees of physical and cognitive impairment. Recent Phase II and III clinical trials of...

Overview of Nitroglycerin-Based Neuroprotection in Acute Ischemic Stroke: A Pilot Randomized Controlled Trial Review Background and Research Objectives Acute ischemic stroke (AIS) is one of the leading global causes of disability and death. Despite the significant improvement in vascular recanalization rates and patient outcomes achieved with moder...

Targeting SNRNP200-Induced Splicing Dysregulation: A New Strategy for Immunotherapy in Glycolytic Triple-Negative Breast Cancer Background Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by extremely high recurrence and mortality rates. Despite significant recent advances in research on TNBC subty...

Report on the Study of Bacterial Toxins Inducing Non-Canonical Migracytosis and Aggravating Acute Inflammation Background and Research Objectives In recent years, the discovery of migrasomes, a new type of membrane structure, has gained significant attention in the scientific community for its role in cell migration and various biological functions...

Background Since the outbreak of the COVID-19 pandemic, SARS-CoV-2 infection has not only affected the respiratory system but has also been closely related to metabolic diseases such as diabetes. Clinical observations have found occurrences of new-onset diabetes and worsening of existing diabetes among COVID-19 patients, particularly with an increa...

Multilayered Tissue Construction of a Micro-intestinal System Reproduces Mesenchymal Flow Research Background In recent years, constructing in vitro models of the human small intestine has made significant progress; however, fully replicating its complex structural and functional characteristics remains challenging. The goal of micro-intestinal tis...

Research Background With global population aging, the number of lung resection surgeries has increased significantly, including primary lung cancer resection, removal of lung metastases, and surgeries to treat lung infections or emphysema. However, little is known about the systemic stress response after thoracic surgery and interventions to improv...

Development of Semi-synthetic Guanidino-lipoglycopeptide Antibiotics and Study of Their In Vitro and In Vivo Antibacterial Activities Background With the slowdown in antimicrobial drug development and the rapid increase of resistant strains, antibiotic resistance has become a major threat to human health. Particularly, Gram-positive pathogens such ...

Academic Report The incidence of global Invasive Fungal Infections (IFIs) has increased over the past few decades, primarily affecting immunocompromised patients, and these infections are often associated with high mortality and morbidity rates. Aspergillus fumigatus is one of the most common and deadly IFI pathogens. The main obstacles to effectiv...

Dengue Virus Research: Impact of Genetic Mutations on Virus Transmission and Discoveries Introduction This study was conducted by Allyson N. X. Choi et al. and published in Science Translational Medicine on July 31, 2024. The research aims to reveal the impact of genetic changes in dengue virus on its transmission ability and disease outbreaks duri...