Differential Gene Expression Analysis Shows That Cephalosporin Resistance is Intrinsic to Clostridioides difficile Strain 630

Medicine, Infectious Diseases, Life Sciences, Biochemistry, Microbiology,
Clostridioides difficile   cephalosporin resistance   gene expression   β-lactamase   ABC transporter   antibiotics   transcriptomic analysis  

Research on Cephalosporin Resistance in C. difficile Background Clostridioides difficile infection (CDI) is one of the most common hospital-acquired infections in the United States, leading to a significant number of hospitalizations and even deaths annually. CDI not only poses a threat to patient health but also imposes a substantial economic burd...

Semisynthetic Guanidino Lipoglycopeptides with Potent In Vitro and In Vivo Antibacterial Activity

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Life Sciences, Biochemistry, Microbiology,
antibiotics   semisynthetic   guanidino   lipoglycopeptides   antibacterial activity   MRSA   multidrug-resistant bacteria  

Development of Semi-synthetic Guanidino-lipoglycopeptide Antibiotics and Study of Their In Vitro and In Vivo Antibacterial Activities Background With the slowdown in antimicrobial drug development and the rapid increase of resistant strains, antibiotic resistance has become a major threat to human health. Particularly, Gram-positive pathogens such ...

Antibiotics-Induced Intestinal Immunomodulation Attenuates Experimental Autoimmune Neuritis (EAN)

Medicine, Infectious Diseases, Rheumatology and Immunology, Neurology, Gastroenterology, Life Sciences, Immunology,
antibiotics   intestinal immunity   experimental autoimmune neuritis   immunomodulation   Guillain-Barré syndrome   gut microbiota  

Antibiotic-Induced Intestinal Immunomodulation Alleviates Experimental Autoimmune Neuritis (EAN) Academic Background Guillain-Barré syndrome (GBS) is an acute autoimmune disease that causes inflammatory demyelination of peripheral nerves. As the most common cause of acute flaccid paralysis, its global annual incidence is 1-4 cases per 100,000 peopl...