Regulation of Calcium Homeostasis in Endoplasmic Reticulum–Mitochondria Crosstalk: Implications for Skeletal Muscle Atrophy

The Critical Role of Calcium in Skeletal Muscle Function and Its Interaction with Mitochondria and the Endoplasmic Reticulum Academic Background Calcium ions (Ca²⁺) are crucial intracellular signaling molecules, particularly in the excitation-contraction coupling (ECC) of skeletal muscle. The contraction of skeletal muscle relies on the release and...