ENPP1 Induces Blood–Brain Barrier Dysfunction and Promotes Brain Metastasis Formation in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

Medicine, Neurology, Neurosurgery, Oncology,
blood-brain barrier   brain metastasis   HER2-positive breast cancer   ENPP1   insulin signaling pathway   endothelial cell dysfunction   prognostic biomarker  

The Role of ENPP1 in Brain Metastasis of HER2-Positive Breast Cancer Academic Background Brain metastasis (BM) is a severe neurological complication in patients with HER2-positive breast cancer (HER2+ BC), with an incidence rate as high as 50%. The formation of brain metastasis is closely related to how tumor cells cross the blood-brain barrier (BB...