Academic Background Pituitary adenomas (PAs) are common intracranial tumors with complex pathogenesis, often accompanied by abnormal hormone secretion. Although various treatments, such as dopamine agonists (DAs), are currently available, some patients exhibit drug resistance, leading to suboptimal therapeutic outcomes. Therefore, identifying new t...
Long-Term Follow-Up Study of Central Nervous System Germ Cell Tumors: Pathology-Based Tripartite Treatment Stratification Academic Background Central nervous system germ cell tumors (CNS GCTs) are rare tumors primarily occurring in adolescents, especially males aged 12 to 16. These tumors are believed to originate from primordial germ cells (PGCs),...
Prospective Longitudinal Analysis of Physiologic MRI-Based Tumor Habitat Predicts Short-Term Patient Outcomes in IDH-Wildtype Glioblastoma Academic Background Glioblastoma (GBM) is a highly malignant brain tumor characterized by significant intratumoral heterogeneity, which is evident not only in gene expression and histopathology but also in macro...
Background Introduction Spinal Cord Injury (SCI) is a significant challenge in the medical field, particularly in terms of neural function recovery. Research indicates that neurons play a crucial role in spinal cord regeneration, but in complex pathological environments, neurons are influenced by various factors, leading to rapid senescence. Senesc...
Academic Background The regenerative capacity of the nervous system varies significantly between different regions. Axons in the peripheral nervous system (PNS) can regenerate spontaneously after injury, whereas axons in the central nervous system (CNS) lack this ability. This difference makes recovery after CNS injury extremely challenging, especi...
Radiation-Induced Cellular Plasticity Primes Glioblastoma for Forskolin-Mediated Differentiation Academic Background Glioblastoma (GBM) is one of the deadliest brain cancers in adults, with a median survival period of only 15 to 18 months for patients. Although surgery combined with chemoradiotherapy can delay disease progression, these treatments ...
The Role of Notch, ERK, and SHH Signaling Pathways in the Fate Determination of Cortical Glial Cells and Olfactory Bulb Interneurons Academic Background During cortical development, neurogenesis and gliogenesis are two closely connected stages. Neurogenesis primarily generates neurons, while gliogenesis produces glial cells, including astrocytes an...
Research on Real-Time 3D Reconstruction and Navigation in Neuroendoscopy Based on Self-Supervised Learning Academic Background Neuroendoscopic surgery, as a minimally invasive surgical technique, is widely used in the treatment of deep brain lesions, such as endoscopic third ventriculostomy (ETV), choroid plexus cauterization, and cyst fenestration...
Causal Associations Between Sleep Traits, Sleep Disorders, and Glioblastoma: A Two-Sample Bidirectional Mendelian Randomization Study Academic Background Introduction Glioblastoma (GBM) is the most aggressive and common type of malignant brain tumor, accounting for nearly 50% of all primary brain tumors in adults. It primarily originates from astro...
Improving Glioblastoma Treatment with Imaging, Radiotherapy, Drug Delivery, and Therapeutic Systems Academic Background Glioblastoma (GBM) is the most common and aggressive type of brain cancer, with an extremely poor prognosis and a five-year survival rate of less than 10%. Despite decades of extensive research in drug therapy, radiation therapy, ...