ENPP1 Induces Blood–Brain Barrier Dysfunction and Promotes Brain Metastasis Formation in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

Medicine, Neurology, Neurosurgery, Oncology,
blood-brain barrier   brain metastasis   HER2-positive breast cancer   ENPP1   insulin signaling pathway   endothelial cell dysfunction   prognostic biomarker  

The Role of ENPP1 in Brain Metastasis of HER2-Positive Breast Cancer Academic Background Brain metastasis (BM) is a severe neurological complication in patients with HER2-positive breast cancer (HER2+ BC), with an incidence rate as high as 50%. The formation of brain metastasis is closely related to how tumor cells cross the blood-brain barrier (BB...

Integrative Molecular and Spatial Analysis Reveals Evolutionary Dynamics and Tumor-Immune Interplay of In Situ and Invasive Acral Melanoma

Integrative Molecular and Spatial Analysis Reveals Evolutionary Dynamics and Tumor-Immune Interplay of In Situ and Invasive Acral Melanoma

Medicine, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
integrative molecular analysis   spatial analysis   acral melanoma   evolutionary dynamics   tumor-immune interplay   early invasion   prognostic biomarker  

Integrated Molecular and Spatial Analysis Reveals Evolutionary Dynamics and Tumor-Immune Interactions in In Situ and Invasive Acral Melanoma Academic Background of the Paper Melanoma is a type of skin cancer, and acral melanoma (AM) is a kind that occurs on non-exposed areas such as the palms, soles, and under the nails and is particularly common a...