Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors

Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors

Obsessive-compulsive behaviors have long been associated with overactivation of the striatum. The GABA-ergic parvalbumin-positive interneurons (PVIs) in the striatum play a crucial role in regulating striatal activity and inhibiting inappropriate motivated behaviors. To investigate the potential role of striatal PVIs in regulating obsessive-compuls...