Uncovering Sex-Specific Epigenetic Regulatory Mechanism Involving H3K9me2 in Neural Inflammation, Damage, and Recovery in the Internal Carotid Artery Occlusion Mouse Model

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
cerebral ischemia   sex-difference   inflammation   KDM4B/JMJD2B   striatum   epigenetics  

Research Reveals Gender-Specific Epigenetic Regulatory Mechanisms in Neuroinflammation, Injury, and Recovery Background Ischemic stroke is one of the leading causes of death and disability worldwide. Due to limited understanding of its linked disease mechanisms, current treatments for alleviating acute ischemic brain injury are very limited. Recent...

Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors

Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors

Medicine, Psychiatry, Neurology, Life Sciences, Biophysics,
compulsive behavior   striatum   parvalbumin interneurons   closed-loop optogenetics   grooming  

Obsessive-compulsive behaviors have long been associated with overactivation of the striatum. The GABA-ergic parvalbumin-positive interneurons (PVIs) in the striatum play a crucial role in regulating striatal activity and inhibiting inappropriate motivated behaviors. To investigate the potential role of striatal PVIs in regulating obsessive-compuls...