Mapping Variant Effects on Anti-tumor Hallmarks of Primary Human T Cells with Base-Editing Screens

Mapping Variant Effects on Anti-tumor Hallmarks of Primary Human T Cells with Base-Editing Screens

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
base editing   T cells   cancer immunotherapy   single-nucleotide variants   gain-of-function   loss-of-function   immune cell therapy  

Application of Base Editing Screening Technology in Tumor Immunotherapy T Cell Research Immune cell therapies, such as T cell transfer therapy and CAR T cell therapy, have become important clinical cancer treatment tools in certain disease fields. However, most cancer patients fail to benefit from cell therapies, possibly due to inherent changes in...