Selective Targeting of Mutated Calreticulin by the Monoclonal Antibody INCA033989 Inhibits Oncogenic Function of MPN

Medicine, Hematology, Oncology, Life Sciences, Immunology,
mutated calreticulin   monoclonal antibody   myeloproliferative neoplasms   targeted therapy   oncogenic function   INCA033989   hematopoiesis  

Report on the Academic Paper on the Monoclonal Antibody INCA033989 for Targeting Mutated Calreticulin in Myeloid Tumors Background: Calreticulin Mutation-Driven Myeloproliferative Neoplasms Myeloproliferative neoplasms (MPNs) are hematological malignancies caused by somatic mutations occurring in multipotent hematopoietic stem cells (HSCs). These m...