Selective Translational Control by PABPC1 Phase Separation Regulates Blast Crisis and Therapy Resistance in Chronic Myeloid Leukaemia
Academic Background and Problem Introduction Chronic Myeloid Leukemia (CML) is a hematologic malignancy driven by the BCR-ABL1 fusion gene. Although Tyrosine Kinase Inhibitors (TKIs) have significantly improved the survival rate of CML patients, TKI resistance and disease progression to the blast crisis (BC) phase remain major challenges in clinica...