Selective Translational Control by PABPC1 Phase Separation Regulates Blast Crisis and Therapy Resistance in Chronic Myeloid Leukaemia

Academic Background and Problem Introduction Chronic Myeloid Leukemia (CML) is a hematologic malignancy driven by the BCR-ABL1 fusion gene. Although Tyrosine Kinase Inhibitors (TKIs) have significantly improved the survival rate of CML patients, TKI resistance and disease progression to the blast crisis (BC) phase remain major challenges in clinica...

Odronextamab Monotherapy in Patients with Relapsed/Refractory Diffuse Large B Cell Lymphoma: Primary Efficacy and Safety Analysis in Phase 2 ELM-2 Trial

Academic Background Diffuse Large B Cell Lymphoma (DLBCL) is an aggressive form of B-cell non-Hodgkin lymphoma (B-NHL), accounting for approximately 30% of all non-Hodgkin lymphomas. Although first-line immunochemotherapy (e.g., R-CHOP regimen) has shown efficacy in DLBCL patients, about 30% of patients relapse or become refractory (relapsed/refrac...

Bone Marrow-Derived NGFR-Positive Dendritic Cells Regulate Arterial Remodeling

Bone Marrow-Derived NGFR+ Dendritic Cells Regulate Arterial Remodeling Background Introduction Atherosclerosis is the primary pathological basis of cardiovascular disease, and its incidence continues to rise globally. Although extensive research has revealed the pathogenesis of atherosclerosis and led to the development of various therapeutic drugs...

Intestinal Epithelium–Derived IL-34 Reprograms Macrophages to Mitigate Gastrointestinal Tract Graft-Versus-Host Disease

Academic Report on the Role of Intestinal Epithelium-Derived IL-34 in Alleviating Graft-versus-Host Disease 1. Academic Background Graft-versus-Host Disease (GVHD) is a severe complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT), and gastrointestinal (GI) GVHD is the primary determinant of morbidity and mortality du...

Organ-Specific Microenvironments Drive Divergent T Cell Evolution in Acute Graft-Versus-Host Disease

Study on Organ-Specific T Cell Differentiation in Acute Graft-Versus-Host Disease (AGVHD) Academic Background Acute Graft-Versus-Host Disease (AGVHD) is a common and severe complication following Allogeneic Hematopoietic Stem Cell Transplantation (HCT), caused by the immune attack of donor T cells on host tissues. Although the pathological mechanis...

NCAPD3 Promotes Diffuse Large B-Cell Lymphoma Progression Through Modulating SIRT1 Expression in an H3K9 Monomethylation-Dependent Manner

Study on the Pro-Cancer Mechanism and Application Value of NCAPD3 in Diffuse Large B-Cell Lymphoma Academic Background Diffuse large B-cell lymphoma (DLBCL) is the most common hematological malignancy, characterized by significant clinical and biological heterogeneity. Although advances in treatment have been made in recent years, a subset of patie...

Real-World Assessment of the Patient Profile, Clinical Characteristics, Treatment Patterns, and Outcomes Associated with Erythropoietic and X-Linked Protoporphyria

Real-world Assessment of Patient Characteristics, Clinical Features, Treatment Patterns, and Outcomes Associated with Erythropoietic Protoporphyria and X-linked Protoporphyria Academic Background Erythropoietic Protoporphyria (EPP) and X-linked Protoporphyria (XLP) are two rare inherited metabolic disorders. The prevalence of EPP varies across coun...

Bioprinted Micro-Clots for Kinetic Analysis of Endothelial Cell-Mediated Fibrinolysis

Breakthrough Research on Micro-Scale Exploration of Thrombolysis Kinetics Research Background and Problem Venous thromboembolism (VTE), a severe health condition, causes approximately 500,000 deaths annually in the United States alone. The occurrence of VTE is closely related to the formation and resistance to dissolution of thrombi in veins, commo...

Potent Function of CD70-Targeted iPSC-Derived CAR-NK Cells Against Tumors and Alloreactive T Cells

Potent Function of CD70-Targeted iPSC-Derived CAR-NK Cells Against Tumors and Alloreactive T Cells

Targeting CD70 with iPSC-Derived CAR-NK Cell Therapy Background and Objectives of the Study Over the past decade, cellular therapy for cancer has revolutionized traditional treatment concepts by introducing the idea of a “living drug.” In particular, chimeric antigen receptor T cell (CAR-T) therapy has drastically improved the efficacy of immunothe...

Three-Dimensional Monitoring of RBC Sedimentation in External Magnetic Fields

Study on Three-Dimensional Monitoring of Red Blood Cell Sedimentation under External Magnetic Fields: A Novel Scientific Perspective Background and Research Objective With the widespread use of electronic devices in modern society, humans are increasingly exposed to external magnetic fields (MFs) in their living environments. However, the potential...