Combining Biological Aging and Genetic Susceptibility to Identify High-Risk Populations for Venous Thromboembolism Academic Background Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most fatal cardiovascular disease globally. The incidence of VTE is closely related to age, particularly i...

CM313 Monotherapy in Patients with Relapsed/Refractory Multiple Myeloma or Marginal Zone Lymphoma: A Multicenter Phase 1 Dose-Escalation and Expansion Trial Academic Background Multiple Myeloma (MM) is a common hematologic malignancy, accounting for approximately one-tenth of all hematologic malignancies. Although the use of immunomodulatory drugs ...

Robust Engraftment of Acute Myeloid Leukemia (AML) in Humanized Scaffolds Background Acute myeloid leukemia (AML) is a malignant blood disorder that poses significant challenges in treatment and research. Patient-derived xenograft (PDX) models are crucial tools for studying AML, but existing PDX models are often complex and labor-intensive, limitin...

WWP1 Regulates Redox State in Acute Myeloid Leukemia Cells by Modulating TXNIP Background Acute myeloid leukemia (AML) is a malignant blood disorder characterized by the abnormal proliferation of immature leukemia cells (leukemic blasts) in the bone marrow. Although significant progress has been made in the treatment of AML in recent years, the lon...

TRIB3 Promotes Multiple Myeloma Progression by Stabilizing SSRP1 via USP10-Mediated Deubiquitination Academic Background Multiple Myeloma (MM) is the second most common hematologic malignancy globally, characterized by aggressive progression, frequent relapse, and resistance to therapy. Although current multi-drug combination therapies have signifi...

The functional decline of the immune system with aging is characterized by an increase in innate immune cells (e.g., granulocytes) and a decrease in adaptive immune cells (e.g., B cells). This imbalance in the immune system is closely related to the onset of various diseases, particularly myeloid leukemia and immune deficiencies common in the elder...

Use of Coagulation Factor Concentrates and Blood Transfusion in Cardiac Surgery: A Retrospective Cohort Study of Adults with Hereditary and Acquired Bleeding Disorders Academic Background Cardiac surgery is one of the high-risk procedures, especially for patients with bleeding disorders, as it significantly increases the risk of perioperative bleed...

Extrinsic Tenase Complexes in Human Saliva Trigger Coagulation in Patients with Severe Hemophilia A Background Introduction Hemophilia A is a hereditary bleeding disorder caused by a deficiency or defect in clotting factor VIII (FVIII), inherited in an X-linked recessive pattern. Patients with severe hemophilia A often experience recurrent joint bl...

Background Introduction Chemotherapy has long been a cornerstone of cancer treatment but is accompanied by significant side effects. Among cancer patients receiving platinum-based chemotherapy drugs (e.g., cisplatin), the incidence of thromboembolic events significantly increases, including pulmonary embolism, cerebrovascular incidents, angina, and...

The Impact of Soluble B-Cell Maturation Antigen (sBCMA) on Multiple Myeloma Therapy: Interpreting the Latest Research Findings In recent years, cell-based immunotherapies have demonstrated enormous promise in the treatment of multiple myeloma (MM). Among these, BCMA-targeting T-cell engagers (TCEs) and chimeric antigen receptor (CAR) T-cell therapi...