Mitochondrial Uncouplers Inhibit Oncogenic E2F1 Activity and Prostate Cancer Growth

Mitochondrial Uncouplers Inhibit Oncogenic E2F1 Activity and Prostate Cancer Growth

Chemistry, Medicinal Chemistry, Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
mitochondrial uncouplers   oncogenic E2F1   prostate cancer   ATP production   AMPK pathway   cell cycle   targeted therapy  

Research Report: Mitochondrial Uncouplers Inhibit E2F1 Activity and Prostate Cancer Growth Background Prostate cancer (PC) is the most common cancer and the second leading cause of cancer-related deaths among men in the United States. In 2024, an estimated 299,010 American men will be diagnosed with prostate cancer, and 35,250 will die from the dis...

Light/pH Dual Controlled Drug Release 'Nanocontainer' Alleviates Tumor Hypoxia for Synergistic Enhanced Chemotherapy, Photodynamic Therapy, and Chemodynamic Therapy

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Bioengineering,
nanocontainer   tumor hypoxia   photodynamic therapy   chemodynamic therapy   Fenton effect   multimodal therapy   targeted therapy  

Light/pH Dual-Controlled Drug Release “Nanocontainer” Alleviates Tumor Hypoxia for Synergistic Enhanced Chemotherapy, Photodynamic Therapy, and Chemodynamic Therapy Academic Background In clinical cancer treatment, chemotherapy and radiotherapy have several limitations, such as drug resistance, incomplete treatment, and periodic recurrence. To over...

Selective Targeting of Mutated Calreticulin by the Monoclonal Antibody INCA033989 Inhibits Oncogenic Function of MPN

Medicine, Hematology, Oncology, Life Sciences, Immunology,
mutated calreticulin   monoclonal antibody   myeloproliferative neoplasms   targeted therapy   oncogenic function   INCA033989   hematopoiesis  

Report on the Academic Paper on the Monoclonal Antibody INCA033989 for Targeting Mutated Calreticulin in Myeloid Tumors Background: Calreticulin Mutation-Driven Myeloproliferative Neoplasms Myeloproliferative neoplasms (MPNs) are hematological malignancies caused by somatic mutations occurring in multipotent hematopoietic stem cells (HSCs). These m...

Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2–Positive Disease

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
breast cancer   brain metastasis   structural rearrangement   cyclin-dependent kinase 12   HER2   genomics   targeted therapy  

Research Report on CDK12 Structural Rearrangements in Brain Metastases of Breast Cancer Background and Purpose Breast Cancer (BC) is the second most common solid tumor involving the Central Nervous System (CNS). Brain Metastases from Breast Cancer (BCBMs) are becoming increasingly common among patients with metastatic breast cancer. Patients with a...

Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Genetics,
MET   kinase domain   point mutation   lung cancer   malignancies   targeted therapy  

This study reveals a new targetable cancer subtype characterized by activating point mutations in the MET tyrosine kinase domain (TKD). Researchers identified MET TKD activating mutations in approximately 0.5% of patients across a genomic data set of over 600,000 cancer cases, encompassing various tumor types, with the highest prevalence in renal c...

Antibody-Displaying Extracellular Vesicles for Targeted Cancer Therapy

Antibody-Displaying Extracellular Vesicles for Targeted Cancer Therapy

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
antibodies   extracellular vesicles   cancer therapy   targeted therapy   immunotherapy  

The Application of Antibodies Displaying Extracellular Vesicles in Targeted Cancer Therapy Extracellular Vesicles (EVs) have been extensively researched as natural delivery carriers and mediators of biological signals in various tissues. In this study, researchers utilized these characteristics of EVs to demonstrate a modular delivery system for ca...