Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: A role for netting neutrophils with resident memory T cells in situ

Medicine, Basic Medical Sciences, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Immunology,
neuromyelitis optica spectrum disorder   multiple sclerosis   neutrophil extracellular DNA traps   melanoma cell adhesion molecule-positive helper T cells   forkhead box P3-positive regulatory T cells   tissue-resident memory T cells  

Stage-Dependent Immune Responses Mediated by AQP4 Antibodies in NMOSD Pathology in the Central Nervous System Academic Background Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune diseases of the central nervous system (CNS), characterized by the production of specific antibodies against the water channel protein Aquaporin-4 (AQP4). Al...