Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Immunology,
microglia   TGFβ-activated kinase-1   CAR T cells   neurotoxicity syndrome  

In this study, researchers explored the role of the TAK1 activation pathway in CAR T cell therapy-associated immune effector cell-associated neurotoxicity syndrome (ICANS). They established a mouse ICANS model and found that following the transfer of CAR19 T cells, cerebellar cells were activated, underwent morphological changes, and expressed more...