Background Introduction Sepsis is a life-threatening multiple organ dysfunction syndrome caused by uncontrolled infection in the host, and is one of the leading causes of death in intensive care units. It is reported that there are approximately 189 adult sepsis hospitalization cases per 100,000 person-years, with a mortality rate of 26.7%. Sepsis-...
TREM2 Expression on Mouse Astrocytes Prevents Sevoflurane-Induced Developmental Neurotoxicity Through Microglial Pruning of Dendritic Spines in Hippocampal CA1 Region Research Background and Significance Sevoflurane is one of the most widely used anesthetics in pediatric anesthesia. Early multiple exposures to sevoflurane can lead to developmental ...
Research on the Effects of Amorfrutin B on Human Microglia under Hypoxia/Ischemia Conditions: Anti-inflammatory Action, Proliferation Potential, and Mitochondrial State Based on the PPARγ Pathway Research Background Hypoxia/ischemia is a major cause of brain injury in both neonatal and adult populations. Perinatal asphyxia and ischemic stroke are l...
Repeated Low-Dose Lipopolysaccharide Pretreatment Improves Behavioral Abnormalities and Aberrant Immune Responses Induced by Repeated Social Defeat Stress Background Stress significantly impacts human health, with chronic stress particularly inducing various physiological and psychological disorders. The hypothalamic-pituitary-adrenal (HPA) axis is...
The Sirtuin 5 Inhibitor MC3482 Ameliorates Microglia-Induced Neuroinflammation following Ischaemic Stroke by Upregulating the Succinylation Level of Annexin-A1 Background Ischaemic stroke is the most common type of stroke and a leading cause of death and disability worldwide. Its pathogenesis is complex, involving processes such as oxidative stress...
JAK1/2 Regulates the Synergistic Effect Between Interferon γ and Lipopolysaccharide in Microglia A research paper titled “JAK1/2 Regulates the Synergistic Effect Between Interferon γ and Lipopolysaccharide in Microglia” was published in the Journal of Neuroimmune Pharmacology in 2024. This article was completed by scholars Alexander P. Young and Ei...
Background Introduction Sterile neuroinflammation is an important factor driving various neurological diseases. Myelin debris, released during the demyelination process in various neurological diseases (such as stroke, spinal cord injury (SCI), multiple sclerosis (MS), traumatic brain injury (TBI), and neurodegenerative diseases), can act as an inf...
Important Research Interpretation from “Journal of Neuroinflammation” 2024: The Impact of Park7/DJ-1 Deficiency on Microglial Activation Academic Background Parkinson’s Disease (PD) is the second most common neurodegenerative disease, characterized by the accumulation of α-synuclein and progressive loss of dopaminergic neurons. Aging is the primary...
The Role of HDAC3 in Retinal Ischemia-Reperfusion Injury Background Retinal ischemia-induced retinal diseases are significant characteristics of common visual impairments such as diabetic retinopathy (DR) and central retinal artery and vein occlusion. The therapeutic effects for these ischemic retinal diseases are generally ineffective, and the des...
The Role of Microglia in Neuroinflammation: Metabolic and Gender Differences in Aging Research Background Aging is a major risk factor for neurodegenerative diseases such as Alzheimer’s Disease (AD) and Parkinson’s Disease. Even healthy aging is accompanied by a decline in cognitive function. Previous research has indicated that microglia undergo s...