Investigation of the Impact of Cross-Frequency Coupling on the Assessment of Depression Severity through the Analysis of Resting State EEG Signals

Background Depression, particularly Major Depressive Disorder (MDD), is a widespread and debilitating psychological disease often described as the “common cold” of mental health. Many people with MDD experience symptoms such as persistent sadness, hopelessness, cognitive impairment, and loss of motivation for daily activities, severely affecting pe...