D1R-5-HT2AR Uncoupling Alleviates Depressive Behaviors Through HDAC Signaling Research Background Major depressive disorder (MDD) is a globally prevalent and life-threatening mental illness, closely associated with poor physical health. Despite the availability of various treatments, including medications and psychotherapy, many patients exhibit po...
A Mechanism of Brainstem Circuit Enhancing Aversion Response Background and Motivation Aversion response is a natural reaction in humans and animals when faced with threats or unpleasant stimuli, allowing individuals to avoid danger and playing a critical role in adaptation during evolution. However, excessive aversion can lead to a range of emotio...
A Study on the Correlation Between Different Learning Abnormalities and Delusional-like Beliefs of Various Contents Research Background Delusions are a major feature of psychotic disorders (such as schizophrenia, bipolar disorder, depression, and certain neurological and autoimmune diseases). Although delusions clinically manifest as fixed erroneou...
Research Report on Progressive Multidimensional Clinical and Radiological Variations in Patients with Alzheimer’s Disease and Posterior Cortical Atrophy Background Introduction Alzheimer’s Disease (AD) has multiple phenotypes, including the typical amnestic and non-amnestic (atypical) phenotypes. Posterior Cortical Atrophy (PCA) is a prominent atyp...
E-cigarette Cessation SMS Program: A Randomized Clinical Trial Study Targeting Adolescent E-cigarette Users Background In recent years, e-cigarettes have become the most widely used tobacco product among American adolescents. Statistics from 2023 show that over 2.1 million adolescents reported current use of e-cigarettes, including 10% of high scho...
Research Report on FMOD Alleviating Depressive Behavior After Traumatic Brain Injury Traumatic Brain Injury (TBI) is a global health issue with far-reaching impacts, causing not only brain dysfunction but also often leading to mental disorders. One of the most common mental illnesses following TBI is depression, affecting approximately 25-50% of TB...
Study on Quantitative Expression and Treatment Response of Latent Disease Factors Underlying Psychopathological Dimensions Revealed by Unsupervised Machine Learning Research Background Heterogeneity and comorbidity are prevalent in psychiatric diagnoses, posing challenges for precise diagnosis and personalized treatment. For instance, Autism Spectr...
Neural computational mechanisms underlying fairness-based decisions: Self-Unfairness and Other-Unfairness Abstract: Fairness is a fundamental value in human society, and individuals show concern for both self-unfairness and other-unfairness. However, there has been a long-standing debate on whether self-unfairness and other-unfairness evoke shared ...
Revealing Different Cognitive Mechanisms of the Ebbinghaus Illusion Through Neural Oscillations Academic Background Human perception of size in vision is not entirely faithful to the physical world and is highly dependent on context. For example, when an object is surrounded by several smaller objects, it appears larger than when surrounded by larg...
Research Background and Objectives Autism Spectrum Disorders (ASDs) are a group of highly heritable neurodevelopmental disorders, primarily characterized by abnormal social interactions, communication deficits, and restricted repetitive behaviors or interests. Previous studies have reported structural changes in brain regions including the hippocam...