Tissue-Resident Memory T Cells Break Tolerance to Renal Autoantigens and Orchestrate Immune-Mediated Nephritis

Medicine, Rheumatology and Immunology, Nephrology, Life Sciences, Immunology,
T cell response   tissue residency   renal autoimmunity   nephritis   CD8  

Special Report: The Role of Tissue-Resident Memory T Cells in Breaking Self-Antigen Immune Tolerance and Immune-Mediated Nephritis in the Kidney Introduction Immune-mediated nephritis is one of the major causes of acute kidney injury and chronic kidney disease. While the role of B cells and antibodies in such diseases has been extensively studied, ...

The Protective Roles of Integrin α4β7 and Amphiregulin-Expressing Innate Lymphoid Cells in Lupus Nephritis

Medicine, Rheumatology and Immunology, Nephrology, Life Sciences, Immunology,
innate lymphoid cells   tissue residency   adhesion molecules   integrins   kidney   lupus nephritis   amphiregulin  

Scientific Research Report: The Protective Role of Integrin α4β7 and Type 2 Innate Lymphoid Cells in Nephritis In a recent study, an international research team led by Dr. Seungwon Ryu revealed the critical protective role of integrin α4β7 and Type 2 Innate Lymphoid Cells (ILC2s) in nephritis caused by Systemic Lupus Erythematosus (SLE). The study ...