Research Background Hypertension is one of the most common and serious health problems worldwide, with its high prevalence closely linked to an increased risk of cardiovascular diseases and stroke. Although the pathogenesis of hypertension is complex and involves multiple organs or systems (such as the kidneys, arteries, microcirculation, heart, an...

The Impact of Persistent Severe Acute Kidney Injury on Outcomes in Critically Ill Patients Background Introduction Acute Kidney Injury (AKI) is a common complication among hospitalized and critically ill patients, causing over 10 million deaths globally each year and serving as a significant risk factor for the progression of Chronic Kidney Disease...

The Role of Major Cardiovascular Surgery-Induced Metabolic Reprogramming in Acute Kidney Injury: A Metabolomics Study Academic Background Cardiovascular diseases are the leading cause of death worldwide, accounting for over 17.9 million deaths annually, which is 32% of all deaths. As the disease burden increases, about one-third of patients may req...

The Relationship Between Serum Chloride Concentration and Intravenous Fluid Therapy Outcomes Background Introduction In the intensive care unit (ICU), intravenous fluid therapy is a common treatment, with “balanced solutions” and 0.9% sodium chloride solution (saline) being the most commonly used fluids. In recent years, multiple randomized control...

Mechanism Study of Dapagliflozin Improving Diabetic Nephropathy via the Gut-Kidney Axis Academic Background Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes, with approximately 40% of individuals with type 1 or type 2 diabetes developing DN in the advanced stages of the disease. Although clinical managemen...

Identification of Polycystin 2 Missense Mutants Targeted for Endoplasmic Reticulum-Associated Degradation Academic Background Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disorder that ultimately leads to end-stage renal disease. ADPKD primarily arises from mutations in the PKD1 and PKD2 genes, which encode Polycystin 1 ...

Chronic Kidney Disease: Runx2-NLRP3 Axis Regulates Matrix Stiffness-Induced Vascular Smooth Muscle Cell Inflammation Academic Background Chronic Kidney Disease (CKD) is a common condition worldwide, leading to high morbidity and mortality rates among patients and significantly increasing the risk of cardiovascular events. Arterial stiffening, chara...

Pathological Link Between Kidney Disease and Parkinson’s Disease Academic Background Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the abnormal aggregation of α-synuclein (α-syn) in the brain, forming Lewy bodies (LBs) and Lewy neurites (LNs). In recent years, increasing evidence suggests that the pathological agg...

Academic Background Chronic autoimmune diseases are typically triggered by a combination of genetic predisposition and environmental factors, with complex and incompletely understood mechanisms. In many cases, these diseases require lifelong immunosuppressive treatments, imposing a heavy burden on patients. Recent research has found that gut microb...

Moscatilin Inhibits Vascular Calcification by Activating IL13RA2-dependent Inhibition of STAT3 and Attenuating the Wnt3/β-catenin Signaling Pathway Background Vascular calcification is a pathological process involving the deposition of hydroxyapatite in the vessel wall, often associated with atherosclerotic cardiovascular disease and chronic kidney...