Use of Coagulation Factor Concentrates and Blood Transfusion in Cardiac Surgery: A Retrospective Cohort Study of Adults with Hereditary and Acquired Bleeding Disorders

Medicine, Anesthesiology, Hematology, Cardiovascular System,
bleeding disorder   cardiac surgery   coagulation factor concentrate   healthcare cost   perioperative bleeding   perioperative complications   transfusion  

Use of Coagulation Factor Concentrates and Blood Transfusion in Cardiac Surgery: A Retrospective Cohort Study of Adults with Hereditary and Acquired Bleeding Disorders Academic Background Cardiac surgery is one of the high-risk procedures, especially for patients with bleeding disorders, as it significantly increases the risk of perioperative bleed...

Gene Therapy: Genetic Engineering of Transfusable Platelets with mRNA-Lipid Nanoparticles is Compatible with Blood Banking Practices

Medicine, Hematology, Life Sciences,
gene therapy   platelets   mRNA-lipid nanoparticles   blood banking   transfusion   cell therapy   clinical compatibility  

Report on the Compatibility of mRNA-Lipid Nanoparticle-Based Gene-Engineered Platelets with Blood Banking Practices Academic Background Platelets play an essential role in hemostasis, inflammation, sepsis, and cancer. However, clinical applications of platelet transfusions are primarily limited to managing thrombocytopenia and bleeding. To broaden ...