Gene Therapy: Genetic Engineering of Transfusable Platelets with mRNA-Lipid Nanoparticles is Compatible with Blood Banking Practices

Report on the Compatibility of mRNA-Lipid Nanoparticle-Based Gene-Engineered Platelets with Blood Banking Practices Academic Background Platelets play an essential role in hemostasis, inflammation, sepsis, and cancer. However, clinical applications of platelet transfusions are primarily limited to managing thrombocytopenia and bleeding. To broaden ...

Mesenchymal Stromal Cells with Chimeric Antigen Receptors for Enhanced Immunosuppression

Mesenchymal Stromal Cells with Chimeric Antigen Receptors for Enhanced Immunosuppression Background Mesenchymal Stromal Cells (MSCs) are pluripotent cells found in almost all tissues and possess significant immunosuppressive and regenerative properties. These features make MSCs widely studied for the treatment of immune diseases and tissue regenera...