Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic B Cell Pyroptosis upon Viral Infection

Background Since the outbreak of the COVID-19 pandemic, SARS-CoV-2 infection has not only affected the respiratory system but has also been closely related to metabolic diseases such as diabetes. Clinical observations have found occurrences of new-onset diabetes and worsening of existing diabetes among COVID-19 patients, particularly with an increa...