HLA-A+ Tertiary Lymphoid Structures with Reactivated Tumor-Infiltrating Lymphocytes Are Associated with a Positive Immunotherapy Response in Esophageal Squamous Cell Carcinoma

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
HLA-A+   Tertiary Lymphoid Structures   Esophageal Squamous Cell Carcinoma   Immunotherapy   Tumor-Infiltrating Lymphocytes   Antigen Presenting Machinery   Gene Expression  

In esophageal squamous cell carcinoma (ESCC), immune checkpoint blockade (ICB) therapy has achieved significant clinical benefits. However, the overall response rate to ICB treatment remains low. This study aims to identify biomarkers for ESCC response to ICB therapy and explore their potential clinical relevance. The authors of the paper come from...