HLA-A+ Tertiary Lymphoid Structures with Reactivated Tumor-Infiltrating Lymphocytes Are Associated with a Positive Immunotherapy Response in Esophageal Squamous Cell Carcinoma

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
HLA-A+   Tertiary Lymphoid Structures   Esophageal Squamous Cell Carcinoma   Immunotherapy   Tumor-Infiltrating Lymphocytes   Antigen Presenting Machinery   Gene Expression  

In esophageal squamous cell carcinoma (ESCC), immune checkpoint blockade (ICB) therapy has achieved significant clinical benefits. However, the overall response rate to ICB treatment remains low. This study aims to identify biomarkers for ESCC response to ICB therapy and explore their potential clinical relevance. The authors of the paper come from...

Persistence and Enrichment of Dominant T Cell Clonotypes in Expanded Tumor-Infiltrating Lymphocytes of Breast Cancer

Medicine, Rheumatology and Immunology, Medical Laboratory Science, Oncology, Life Sciences, Immunology,
Tumor-Infiltrating Lymphocytes   Breast Cancer   T Cell Clonotypes   Rapid Expansion   Immunotherapy   Ex Vivo Expansion   Memory T Cells  

Research Report: Dominance and Persistence of T-Cell Clones in Tumor-Infiltrating Lymphocytes during Expansion in Breast Cancer Background Tumor-infiltrating lymphocytes (TILs) are lymphocytes that naturally infiltrate the tumor microenvironment and exhibit reactivity to the tumor. This subject is one of the most actively researched areas in tumor ...