Chemical Activation of Mitochondrial CLPP to Modulate Energy Metabolism of CD4+ T Cell for Inflammatory Bowel Diseases Treatment

Medicine, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
Inflammatory Bowel Disease   Mitochondrial CLPP   CD4+ T Cells   Oxidative Phosphorylation   Th17/Treg Balance  

Academic Background Inflammatory Bowel Disease (IBD) is a chronic, relapsing autoimmune disorder primarily comprising Crohn’s Disease (CD) and Ulcerative Colitis (UC). The exact pathogenesis of IBD remains unclear, but it is known that abnormal immune responses play a critical role in its development, particularly the imbalance of CD4+ T cells. The...