Chemical Activation of Mitochondrial CLPP to Modulate Energy Metabolism of CD4+ T Cell for Inflammatory Bowel Diseases Treatment

Medicine, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
Inflammatory Bowel Disease   Mitochondrial CLPP   CD4+ T Cells   Oxidative Phosphorylation   Th17/Treg Balance  

Academic Background Inflammatory Bowel Disease (IBD) is a chronic, relapsing autoimmune disorder primarily comprising Crohn’s Disease (CD) and Ulcerative Colitis (UC). The exact pathogenesis of IBD remains unclear, but it is known that abnormal immune responses play a critical role in its development, particularly the imbalance of CD4+ T cells. The...

Cyanobacteria–Probiotics Symbionts for Modulation of Intestinal Inflammation and Microbiome Dysregulation in Colitis

Medicine, Gastroenterology, Life Sciences, Microbiology,
Inflammatory Bowel Disease   Cyanobacteria   Probiotics   Hydrogen Gas   Gut Microbiota  

Cyanobacteria–Probiotics Symbionts for Modulation of Intestinal Inflammation and Microbiome Dysregulation in Colitis Academic Background Inflammatory Bowel Disease (IBD) is a group of chronic inflammatory conditions of the gut, primarily including Crohn’s Disease (CD) and Ulcerative Colitis (UC). The pathogenesis of IBD is complex, involving dysfun...