TSH/TSHR Signaling Promotes CD8+ T Cell Exhaustion and Immune Evasion in Colorectal Cancer Background Colorectal cancer (CRC) is one of the most common malignancies worldwide with high morbidity and mortality rates. Although immune checkpoint blockade (ICB) therapy has shown significant efficacy in some patients, the majority of CRC patients, parti...

Academic Background and Paper Introduction Background The Wnt/β-catenin signaling pathway is dysregulated in various cancers, particularly in colorectal and endometrial cancers. Abnormal activation of this pathway is often associated with mutations in tumor suppressor genes such as APC, AXIN1/2, and β-catenin itself. Additionally, RNF43 and ZNRF3, ...

Academic Background and Problem Statement Gastric Cancer (GC) is one of the most common cancers worldwide, with approximately 1.1 million new cases diagnosed in 2020. Although advancements in early detection, surgical techniques, and oncology have led to a decline in GC mortality, the treatment of advanced or metastatic GC remains a significant cha...

lgals9b Stabilizes eef1d Protein and Activates the PI3K/AKT Signaling Pathway to Promote Gastric Cancer Occurrence and Metastasis Academic Background Gastric cancer ranks as the fifth most prevalent cancer globally, with over one million new cases diagnosed annually. Due to late detection, it exhibits a high mortality rate and is the fourth leading...

Metabolic Rewiring Controlled by HIF-1α Tunes IgA-Producing B-Cell Differentiation and Intestinal Inflammation Background Introduction Germinal centers (GC) are critical sites for the clonal expansion of immune B cells and the affinity maturation of antibodies, as well as the occurrence of antibody class switching. Within the GC, B cells undergo so...

Review of the Study “Esophageal ILC2s Mediate Abnormal Epithelial Remodeling in Eosinophilic Esophagitis via AREG-EGFR Signaling” Background Overview Eosinophilic Esophagitis (EoE) is a chronic allergic disease that has shown a significant increase in prevalence in recent years. It is characterized by eosinophil infiltration and epithelial thickeni...

The Spatial Impact of a Western Diet in Enriching Galectin-1-Regulated Rho, ECM, and SASP Signaling in a Novel MASH-HCC Mouse Model Academic Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and metabolic dysfunction-associated steatohepatitis (MASH) is one of the primary triggers of HCC. With ...

Diagnostic Accuracy of CT for the Detection of Hepatic Steatosis: A Systematic Review and Meta-Analysis Academic Background Hepatic steatosis is the result of the abnormal accumulation of triglycerides in hepatocytes, which can initiate a cascade of inflammatory responses, referred to as steatotic liver disease (SLD). Metabolic dysfunction–associat...

Combined Single-Cell and Spatial Transcriptome Analysis Reveals Cellular Heterogeneity of the Hedgehog Pathway in Gastric Cancer Academic Background Gastric cancer (GC) is one of the most common and deadly malignancies worldwide, with high incidence and mortality rates. Despite advancements in chemotherapy, radiotherapy, and targeted therapy, the t...

Regulatory T Cells-Related Gene in Primary Sclerosing Cholangitis: Evidence from Mendelian Randomization and Transcriptome Data Authors: Jianlan Hu1, Youxing Wu1, Danxia Zhang1, Xiaoyang Wang1, Yaohui Sheng1, Hui Liao1, Yangpeng Ou2✉, Zhen Chen3, Baolian Shu1✉, and Ruohu Gui1✉ Journal: Genes & Immunity (2024) 25:492–513 DOI: https://doi.org/10.1038...