Metabolism of Primary High-Grade Serous Ovarian Carcinoma (HGSOC) Cells under Limited Glutamine or Glucose Availability

Medicine, Obstetrics and Gynecology, Oncology,
High-Grade Serous Ovarian Carcinoma   Metabolic Flexibility   Oxidative Phosphorylation   Endoplasmic Reticulum Stress   Chemotherapy Resistance  

Metabolism of High-Grade Serous Ovarian Carcinoma (HGSOC) Cells Academic Background High-Grade Serous Ovarian Carcinoma (HGSOC) is the most common and aggressive subtype of epithelial ovarian cancer. Most patients are diagnosed at stage III or IV, with a 5-year survival rate ranging from 20% to 40%. Treatment for HGSOC typically involves surgical r...

Chemical Activation of Mitochondrial CLPP to Modulate Energy Metabolism of CD4+ T Cell for Inflammatory Bowel Diseases Treatment

Medicine, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
Inflammatory Bowel Disease   Mitochondrial CLPP   CD4+ T Cells   Oxidative Phosphorylation   Th17/Treg Balance  

Academic Background Inflammatory Bowel Disease (IBD) is a chronic, relapsing autoimmune disorder primarily comprising Crohn’s Disease (CD) and Ulcerative Colitis (UC). The exact pathogenesis of IBD remains unclear, but it is known that abnormal immune responses play a critical role in its development, particularly the imbalance of CD4+ T cells. The...

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Acute Myeloid Leukemia   Stem Cells   Mitochondrial Calcium   Oxidative Phosphorylation   Drug Resistance  

This is an academic paper report on the study of acute myeloid leukemia (AML) stem cells. The study found that venetoclax treatment targeting the BCL-2 protein induces different mitochondrial calcium signaling changes in drug-sensitive and drug-resistant AML stem cells, thereby affecting their oxidative phosphorylation metabolism and survival. The ...