GDF15 Propeptide Promotes Bone Metastasis of Castration-Resistant Prostate Cancer by Augmenting the Bone Microenvironment

Research Objective This study aims to identify specific proteins secreted by prostate cancer cells through comprehensive proteomic analysis and explore their role in bone metastasis, with the goal of discovering blood biomarkers that can improve the prognosis of patients with metastatic castration-resistant prostate cancer (mCRPC). Research Team an...

Real-World Overall Survival and Treatment Patterns by PTEN Status in Metastatic Castration-Resistant Prostate Cancer

Overall Survival and Treatment Patterns in Metastatic Castration-Resistant Prostate Cancer Patients Based on PTEN Status Academic Background Prostate cancer is one of the most common malignant tumors among men worldwide and a leading cause of cancer-related deaths. Approximately 10%-20% of prostate cancer patients will develop castration-resistant ...

Circulating and Imaging Biomarkers of Radium-223 Response in Metastatic Castration-Resistant Prostate Cancer

Circulating and Imaging Biomarkers of Radium-223 Response in Metastatic Castration-Resistant Prostate Cancer

Background of Urgent Problem Prostate cancer is one of the most common cancers among men. Metastatic castration-resistant prostate cancer (mCRPC) is an advanced form of prostate cancer characterized by resistance to castration therapy. Radium-223 is an α-emitting radiopharmaceutical that has been shown to improve overall survival (OS) and reduce sk...