The Role of KV7 Channels in Modulating Tension and Calcium Signaling in Mouse Corpus Cavernosum

Study on the Role of KV7 Channels in Regulating Smooth Muscle Contraction in Mouse Corpus Cavernosum Academic Background Erectile dysfunction (ED) is a significant health issue that impacts the quality of life for men. Since the introduction of phosphodiesterase 5 (PDE5) inhibitors like Sildenafil in the 1990s, there has been notable progress in th...

Identification of Polycystin 2 Missense Mutants Targeted for Endoplasmic Reticulum-Associated Degradation

Identification of Polycystin 2 Missense Mutants Targeted for Endoplasmic Reticulum-Associated Degradation Academic Background Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disorder that ultimately leads to end-stage renal disease. ADPKD primarily arises from mutations in the PKD1 and PKD2 genes, which encode Polycystin 1 ...

Propagation of Pathologic α-Synuclein from Kidney to Brain May Contribute to Parkinson’s Disease

Pathological Link Between Kidney Disease and Parkinson’s Disease Academic Background Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the abnormal aggregation of α-synuclein (α-syn) in the brain, forming Lewy bodies (LBs) and Lewy neurites (LNs). In recent years, increasing evidence suggests that the pathological agg...

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups

Multi-Ancestry Genome-Wide Association Study Reveals New Loci for Prostate-Specific Antigen Levels and Improves Prediction Across Ancestral Groups Research Background and Problem Statement Prostate-specific antigen (PSA) is a protein secreted by the prostate gland, commonly used for prostate cancer screening. However, PSA levels are influenced not ...

Kidney Fibrosis in In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models

Mechanisms and Research Models of Kidney Fibrosis: Progress Toward Physiologically Relevant Humanized Models Research Background and Problem Statement Chronic Kidney Disease (CKD) is a major global public health issue, estimated to affect more than 10% of the population and is one of the leading causes of mortality. Kidney fibrosis, as a key pathol...

PSMA PET/CT-based Multimodal Deep Learning Model for Accurate Prediction of Pelvic Lymph-Node Metastases in Prostate Cancer

In-depth Analysis of PSMA PET/CT-based Multimodal Deep Learning Model for Predicting Lymph Node Metastases in Prostate Cancer Patients Background Prostate cancer (PCA) is one of the most common malignant tumors in men and a leading cause of cancer-related deaths. In clinically localized prostate cancer patients, extended pelvic lymph node dissectio...

Ultra-Fast PSMA-PET Staging in Prostate Cancer Enhanced by Artificial Intelligence

Application of AI-Enhanced Ultra-Fast PSMA-PET in Prostate Cancer Staging Academic Background Prostate cancer is one of the most common cancers among men globally, and accurate diagnosis and staging are crucial for treatment decision-making. Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) has become a standard examinati...

Evaluating the Effectiveness of Cytoreductive Surgery in Oligometastatic Prostate Cancer: Insights from Quantitative Analysis and Retrospective Cohort Studies

Evaluating the Effectiveness of Cytoreductive Surgery in Oligometastatic Prostate Cancer Academic Background Prostate cancer is the second most common malignancy among men globally, particularly in its advanced stages, where it is often accompanied by metastases, significantly impacting patients’ quality of life and prognosis. Oligometastatic prost...

Reoperation for Ipsilateral Local Recurrence Following Prior Nephron-Sparing Surgery: Innovative Surgical Insights from a High-Volume Urological Center with Cross-Sectional Study

Innovative Surgical Strategies for Reoperation of Local Recurrence in Renal Cell Carcinoma Academic Background Renal cell carcinoma (RCC) is one of the most common malignant tumors in adults, accounting for 5% of malignancies in males and 3% in females. Although surgery remains the standard treatment for localized RCC, nephron-sparing surgery (NSS)...

Clinical Significance of Stratifying Prostate Cancer Patients Through Specific Circulating Genes

Clinical Significance of Stratifying Prostate Cancer Patients Through Specific Circulating Genes Academic Background Prostate Cancer (PCA) is the most common cancer among men in North America and a leading cause of cancer-related mortality. Although many patients are diagnosed with organ-confined disease, 25-35% experience recurrence after curative...