LOXL1-AS1 Inhibits JAK2 Ubiquitination and Promotes Cholangiocarcinoma Progression through JAK2/STAT3 Signaling

LOXL1-AS1 Promotes Cholangiocarcinoma Progression by Regulating the JAK2/STAT3 Signaling Pathway Academic Background Cholangiocarcinoma (CCA) is a malignant tumor originating from biliary epithelium, presenting significant medical challenges. Its incidence shows geographical variation, being particularly high in Asia and South America. The occurren...

Mechanism of SRC Inhibition in IDH-Mutant Cholangiocarcinoma

Scientists Reveal the Anti-Tumor Mechanism of Src Inhibitors in IDH Mutant Cholangiocarcinoma Background Introduction In recent years, the incidence of intrahepatic cholangiocarcinoma (ICC) has been rising worldwide. ICC is a highly invasive tumor usually lacking noticeable symptoms in the early stages, with cases often being inoperable by the time...