Clinicogenomic Landscape of Pancreatic Ductal Adenocarcinoma: The Prognostic Role of KRAS Mutation Dosage Academic Background Pancreatic ductal adenocarcinoma (PDAC), the most common histological type of pancreatic cancer, is the third leading cause of cancer-related mortality and has the lowest five-year survival rate among all cancer types. Over ...

CDC42 Plays a Crucial Role in the Early Regulation of Hepatic Stellate Cell Activation Academic Background Liver fibrosis is a pathological process associated with various liver diseases, which may eventually progress to cirrhosis—a life-threatening condition. Currently, there are no effective treatments to halt the progression of liver fibrosis. H...

NAD+ Protects Hepatocytes Against Palmitate-Induced Lipotoxicity by Preventing PARP-1 Inhibition and mTORC1-p300 Pathway Activation Research Background Metabolic dysfunction-associated fatty liver disease (MAFLD) encompasses a spectrum of liver diseases ranging from simple steatosis to steatohepatitis, fibrosis/cirrhosis, and even hepatocellular ca...

Breakthrough in Gene Therapy: Repair Drive Technology Enables In Vivo Expansion of Hepatocytes Academic Background Gene therapy has become a hot topic in medical research in recent years, especially for liver diseases. Due to the central role of the liver in metabolism, it has become a critical target for research. Although existing gene-editing te...

Study on Organ-Specific T Cell Differentiation in Acute Graft-Versus-Host Disease (AGVHD) Academic Background Acute Graft-Versus-Host Disease (AGVHD) is a common and severe complication following Allogeneic Hematopoietic Stem Cell Transplantation (HCT), caused by the immune attack of donor T cells on host tissues. Although the pathological mechanis...

HNRNPR-Mediated UPF3B mRNA Splicing Drives Hepatocellular Carcinoma Metastasis In recent years, hepatocellular carcinoma (HCC) has become one of the leading causes of cancer-related deaths worldwide due to its highly invasive and metastatic nature. The mechanisms underlying HCC metastasis are complex, with abnormal alternative splicing (AS) playing...

Potential Therapeutic Role of Dietary Isothiocyanate Compounds in Alpha-1 Antitrypsin Deficiency (AATD) Background and Significance of the Study Alpha-1 Antitrypsin Deficiency (AATD) is a congenital, monogenic disease primarily caused by the misfolding of alpha-1 antitrypsin (AAT) in the liver. This misfolding leads to two pathological effects: the...

Utilizing Bifurcated Allogeneic Vein Grafts to Prevent Sinistral Portal Hypertension Following Pancreaticoduodenectomy Academic Background Pancreatic cancer is a highly malignant tumor with a poor prognosis, with a 5-year survival rate of less than 10%. The early invasive growth of pancreatic cancer often involves the portal vein system, particular...

Study on the Pattern and Extent of Intrahepatic Infiltration in Perihilar Cholangiocarcinoma Academic Background Perihilar cholangiocarcinoma (PHCC) is one of the most common malignancies of the biliary system, and its treatment primarily relies on radical surgical resection. However, despite advancements in surgical techniques, the postoperative r...

Study on the Application of Hepatic Arterial Chemotherapy Combined with Targeted and Immunotherapy in Advanced Liver Cancer Background Liver cancer is the sixth most commonly diagnosed cancer globally and the third leading cause of cancer-related deaths. Most patients are diagnosed at an advanced stage, losing the opportunity for surgical resection...