GITR Exacerbates Lysophosphatidylcholine-induced Macrophage Pyroptosis in Sepsis via Posttranslational Regulation of NLRP3

Research Background Sepsis is a life-threatening organ dysfunction syndrome caused by the body’s abnormal response to microbial infection. It has high morbidity and mortality, mainly due to excessive inflammatory response and metabolic disorders. Studies have shown that myeloid cells (such as monocytes and macrophages) play a key role in the pathog...