Epigallocatechin-3-Gallate Inhibits LPS/AβO-Induced Neuroinflammation in BV2 Cells Through Regulating the ROS/Txnip/NLRP3 Pathway

Medicine, Basic Medical Sciences, Neurology, Pharmacy, Life Sciences, Cell Biology, Biochemistry,
Alzheimer's Disease   Amyloid β   Epigallocatechin-3-Gallate   NLRP3 Inflammasome   Txnip  

Epigallocatechin-3-Gallate (EGCG) Inhibits Neuroinflammation in BV2 Cells by Regulating the ROS/TXNIP/NLRP3 Pathway Research Background Alzheimer’s Disease (AD) is a degenerative brain disorder primarily affecting the elderly, characterized by persistent cognitive dysfunction and behavioral impairment. The neuropathological changes in AD include β-...

GITR Exacerbates Lysophosphatidylcholine-induced Macrophage Pyroptosis in Sepsis via Posttranslational Regulation of NLRP3

Medicine, Infectious Diseases, Rheumatology and Immunology, Life Sciences, Immunology,
GITR   Macrophage   NLRP3 Inflammasome   Sepsis   Posttranslational Modification  

Research Background Sepsis is a life-threatening organ dysfunction syndrome caused by the body’s abnormal response to microbial infection. It has high morbidity and mortality, mainly due to excessive inflammatory response and metabolic disorders. Studies have shown that myeloid cells (such as monocytes and macrophages) play a key role in the pathog...