Chaperone- and PTM-mediated Activation of IRF1 Tames Radiation-induced Cell Death and the Inflammatory Response

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Interferon Regulatory Factor 1   Ionizing Radiation   Nuclear Translocation   Posttranslational Modification   Transcription Regulation  

Study on IRF1 Transcriptional Activation Regulation of Radiation-Induced Cell Death and Inflammatory Response under Mutagenic Stress Background Recent multi-omics studies have revealed the key role of structural cells in immune regulation, but the mechanism remains unclear. Based on this, this study mainly explores how the transcriptional activatio...

GITR Exacerbates Lysophosphatidylcholine-induced Macrophage Pyroptosis in Sepsis via Posttranslational Regulation of NLRP3

Medicine, Infectious Diseases, Rheumatology and Immunology, Life Sciences, Immunology,
GITR   Macrophage   NLRP3 Inflammasome   Sepsis   Posttranslational Modification  

Research Background Sepsis is a life-threatening organ dysfunction syndrome caused by the body’s abnormal response to microbial infection. It has high morbidity and mortality, mainly due to excessive inflammatory response and metabolic disorders. Studies have shown that myeloid cells (such as monocytes and macrophages) play a key role in the pathog...