Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis of a Randomized Clinical Trial

Medicine, Ophthalmology, Life Sciences, Genetics,
Primary Open-Angle Glaucoma   Polygenic Risk Score   Disease Onset Risk   Randomized Clinical Trial   Post Hoc Analysis   Intraocular Pressure   Genetic Risk  

Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis Academic Background Primary open-angle glaucoma (POAG) is the most common form of glaucoma, often associated with elevated intraocular pressure (IOP). It is an irreversible optic neuropathy that, if untreated, can lead to vision loss. While IOP-lowering ...

APOE4 Homozygosity Represents a Distinct Genetic Form of Alzheimer’s Disease

Medicine, Basic Medical Sciences, Neurology,
APOE4   Alzheimer’s Disease   Biomarkers   Genetic Risk   Clinical Study  

APOE4 Homozygotes Represent a Unique Genotypic Subset of Alzheimer’s Disease Introduction Alzheimer’s disease (AD) is one of the neurodegenerative diseases that modern medicine has yet to conquer, usually with a complex genetic background. While mutations in three genes (APP, PSEN1, and PSEN2) lead to early-onset autosomal dominant Alzheimer’s dise...