Gut Microbiota-Derived Indole-3-Acetic Acid (3-IAA) Suppresses High Myopia Progression by Promoting Type I Collagen Synthesis Background High myopia (HM) is a serious vision-threatening ocular condition associated with complications such as glaucoma, cataracts, and macular degeneration. Currently, effective interventions for high myopia are lacking...
Reversible Regulation of Retinal and Peripheral Nerve Function: Physiological Study of Serine and Glycine Background and Research Motivation Macular Telangiectasia Type 2 (Mactel) is an age-related retinal disease characterized by central vision loss. The molecular etiology of this disease is complex and is primarily associated with the metabolism ...
Study on Macular Degeneration Reveals Inhibitory Effect of Natural Killer Cells on Disease Progression Background Age-related Macular Degeneration (AMD) is the leading cause of irreversible blindness among the elderly globally. With an aging population, the incidence of AMD is significantly increasing. Early features of AMD include the accumulation...
Diabetic Retinopathy as a Ceramide Disease Reversible by Anti-Ceramide Immunotherapy Background Diabetic Retinopathy (DR) is one of the most common metabolic disorders worldwide. Diabetes not only leads to chronic complications in macrovascular and microvascular systems but also imposes significant socio-economic burdens. As a microvascular complic...
The Effect of Immunosuppression on the Risk of Generalization in Ocular Myasthenia Gravis Background Ocular Myasthenia Gravis (OMG) is an early and localized manifestation of Myasthenia Gravis (MG), with many patients initially presenting with ocular symptoms such as fatigable ptosis and diplopia. Approximately 85% of MG patients initially exhibit ...
Scientific Research Report: Drug Treatment Alleviates Retinal Ganglion Cell Death in Normal Tension Glaucoma Mouse Model by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation Background Normal Tension Glaucoma (NTG) is a progressive neurodegenerative disease in the glaucoma family. Typically, glaucoma is associated with elevated intra...
Improving the Interpretation of PAX6 Gene Missense Variants Through Computational Methods Background The PAX6 gene is a highly conserved transcription factor that plays a crucial role in eye development. Heterozygous loss-of-function variants in PAX6 can lead to a range of ophthalmic disorders, including aniridia. However, many PAX6 gene missense v...
New Discovery: Study on the Association between GJA8 Gene Mutations and Familial Aniridia-Microphthalmia-Cataract Syndrome Research Background Normal eye development is a process that requires the coordinated action of multiple genes and factors. Abnormal eye development can lead to congenital eye malformations such as anophthalmia, microphthalmia,...
Mechanism Study of High Magnesium Promoting Binocular Vision Recovery in Amblyopia Patients: The Role of TRPM7 Abnormal visual experiences during critical periods of brain development can lead to visual function deficits, such as amblyopia. Current research suggests that high magnesium (Mg^2+) supplementation can restore synaptic plasticity in the ...
The purpose of this paper is to explore the developmental origin, biological characteristics, and association with eye diseases of tissue-resident macrophages in the field of ophthalmology—hyalocytes. The eye is a highly specialized sensory organ that contains the retina, part of the central nervous system, as well as non-neuronal parts like the tr...