Limitations in Next-Generation Sequencing-Based Genotyping of Breast Cancer Polygenic Risk Score Loci

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Biochemistry, Genetics,
Next-Generation Sequencing   Breast Cancer   Polygenic Risk Score   Genotyping   Variant Allele Frequencies   Genetic Counseling   Bioinformatics  

Limitations of Next-Generation Sequencing-Based Genotyping for Breast Cancer Polygenic Risk Score Loci Background Introduction In the prediction of hereditary Breast Cancer (BC), Polygenic Risk Scores (PRSs) are increasingly being used as an important tool for individual risk prediction. The calculation of PRS relies on accurately reproducing varia...

Genome, HLA and Polygenic Risk Score Analyses for Prevalent and Persistent Cervical Human Papillomavirus (HPV) Infections

Medicine, Infectious Diseases, Obstetrics and Gynecology, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
Genome   HLA   Polygenic Risk Score   Cervical HPV   Persistent Infection  

Genome-wide and Polygenic Risk Score Analysis of High-Risk Human Papillomavirus (hrHPV) Infection in the Cervix Background Cervical high-risk human papillomavirus (hrHPV) infection is the second largest carcinogenic infection globally, accounting for approximately 31.4% of all infection-related cancers (about 690,000 cases out of 2.2 million cancer...

Joint Impact of Polygenic Risk Score and Lifestyles on Early- and Late-Onset Cardiovascular Diseases

Medicine, Cardiovascular System,
Polygenic Risk Score   Lifestyles   Cardiovascular Diseases   Early-Onset   Late-Onset   China   Prevention  

Comprehensive Analysis of the Joint Impact of Polygenic Risk Scores and Lifestyle on Cardiovascular Disease Incidence: A Report from the China Kadoorie Biobank Introduction Cardiovascular disease (CVD) is one of the major global health threats. Despite the stable or declining incidence and prevalence of CVD among adults over 50 in recent decades, t...