Hexokinase 2 Senses Fructose in Tumor-Associated Macrophages to Promote Colorectal Cancer Growth

Hexokinase 2 Senses Fructose in Tumor-Associated Macrophages to Promote Colorectal Cancer Growth

Fructose Promotes Colorectal Cancer Growth by Modulating Tumor-Associated Macrophage Polarization Introduction In recent years, fructose intake has dramatically increased worldwide and is closely associated with obesity and metabolic syndrome, both of which are recognized risk factors for cancer development. Although previous studies have shown tha...

Hepatic Danger Signaling Triggers TREM2+ Macrophage Induction and Drives Steatohepatitis via MS4A7-Dependent Inflammasome Activation

Liver Danger Signal Triggers TREM2+ Macrophage-Mediated MS4A7-Dependent Inflammasome Activation Driving Steatohepatitis Background and Research Motivation In recent years, with the increasing incidence of metabolic dysfunction-associated steatohepatitis (MASH), its pathological mechanisms have garnered significant attention. MASH, formerly known as...