ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-targeted Therapy Resistance in Prostate Cancer

ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-targeted Therapy Resistance in Prostate Cancer

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Prostate Cancer   Therapy Resistance   Lineage Plasticity   ZNF397   TET2  

ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer Academic Background and Research Motivation Existing research evidence suggests that cancer cell lineage plasticity and epigenetic reprogramming enable them to evade lineage-dependent targeted therapy by adopting lineage plasticity. Howev...