Subtype-Specific Differences in Metabolic Profiles of Pancreatic Cancer Tumor Organoids

Medicine, Oncology, Life Sciences, Biochemistry,
Pancreatic cancer   Metabolic reprogramming   Glycolysis   Oxidative phosphorylation   Tumor organoids   Subtype-specific   Mitochondrial pyruvate carrier  

Metabolic Characteristics of Pancreatic Ductal Adenocarcinoma (PDAC) Subtypes Background Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive cancer with a five-year survival rate of only 13%, making it the third leading cause of cancer-related deaths. The aggressiveness and chemoresistance of PDAC are closely linked to its complex metabo...

Glycometabolic Reprogramming-Induced XRCC1 Lactylation Confers Therapeutic Resistance in ALDH1A3-Overexpressing Glioblastoma

Medicine, Neurosurgery, Oncology, Life Sciences, Cell Biology, Biochemistry,
Glioblastoma   Metabolic reprogramming   Lactylation   Therapeutic resistance   ALDH1A3   DNA repair  

Background Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor in adults, characterized by high recurrence and mortality rates. Despite active chemotherapy and radiotherapy post-surgery, GBM remains insensitive to existing treatment regimens, and patients usually have a poor prognosis. Recent studies indicate that the...