Background Glioblastoma (GBM) is a highly aggressive central nervous system malignancy with very poor prognosis, typically associated with short patient survival. Although significant advancements have been made in tumor treatment technologies and strategies in recent years, traditional radiotherapy and chemotherapy still struggle to achieve satisf...
The Role of the Novel Circular RNA circZEB1 in the Malignant Phenotype of Glioblastoma Stem Cells and Its Molecular Mechanism Research Background Glioblastoma (GBM) is one of the most aggressive and fatal primary tumors in the central nervous system, with a very poor prognosis for patients. Even with surgery, radiotherapy, and chemotherapy, the ave...
Background Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor in adults, characterized by high recurrence and mortality rates. Despite active chemotherapy and radiotherapy post-surgery, GBM remains insensitive to existing treatment regimens, and patients usually have a poor prognosis. Recent studies indicate that the...
Globally, the most common and deadly malignant brain tumor is glioblastoma (Glioblastoma, GBM). In recent years, research has continuously attempted to predict the overall survival time (OS) of GBM patients using machine learning techniques based on preoperative single-modality or multi-modality imaging phenotypes. Although these machine learning m...
The research results, completed in collaboration by many scientists including Lishu Chen, Qinghui Qi, and Xiaoqing Jiang, were published in the groundbreaking journal Cancer Discovery. The report detailed how phosphocreatine (PCr) promotes the growth of glioblastoma (GBM) by stabilizing bromodomain-containing protein 2 (BRD2). This discovery provid...
Identification of Therapeutic Potential of Hypoxic Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) and isocitrate dehydrogenase (IDH) mutant gliomas are the most common malignant brain tumors in adults. Tumor-associated macrophages (TAMs) are the major immune cell infiltrates in these tumors. These cells interact directly with ma...