Isolation and Identification of Three New Isomer Impurities in Milbemycin Oxime Drug Substance

Chemistry, Analytical Chemistry, Medicinal Chemistry, Medicine, Pharmacy,
Milbemycin Oxime   Isomer Impurities   Isolation   Identification   Drug Analysis   HPLC   NMR  

Isolation and Identification of Three New Isomer Impurities in Milbemycin Oxime Drug Substance Academic Background Milbemycins are a class of 16-membered macrolides produced by Streptomyces, exhibiting potent anthelmintic and insecticidal activities with low mammalian toxicity. Milbemycins and their derivatives are widely used in agriculture and ve...