Speciation-Dependent Molecular Mechanism of Electron Transfer from the c-Type Cytochrome MtrC to U(VI)-Ligand Complexes

Chemistry, Inorganic Chemistry, Environmental Chemistry, Earth Sciences, Geochemistry, Life Sciences, Microbiology,
c-type cytochrome   electron transfer   reduction kinetics   NMR   HR-XANES  

Uranium (U) is a radioactive element widely present in the environment, primarily existing in its hexavalent (U(VI)) and tetravalent (U(IV)) oxidation states. Under oxidizing conditions, U(VI) is the dominant stable form, while under reducing conditions, U(VI) can be reduced to U(IV). This reduction process can occur through abiotic pathways (e.g.,...

Isolation and Identification of Three New Isomer Impurities in Milbemycin Oxime Drug Substance

Chemistry, Analytical Chemistry, Medicinal Chemistry, Medicine, Pharmacy,
Milbemycin Oxime   Isomer Impurities   Isolation   Identification   Drug Analysis   HPLC   NMR  

Isolation and Identification of Three New Isomer Impurities in Milbemycin Oxime Drug Substance Academic Background Milbemycins are a class of 16-membered macrolides produced by Streptomyces, exhibiting potent anthelmintic and insecticidal activities with low mammalian toxicity. Milbemycins and their derivatives are widely used in agriculture and ve...