Aztreonam-Avibactam Activity Against Multidrug-Resistant Klebsiella pneumoniae Complex Background The Klebsiella pneumoniae complex (KPC) is a group of opportunistic pathogens that pose a serious threat to public health. In recent years, the infection rate of multidrug-resistant (MDR) Klebsiella pneumoniae has significantly increased, leading to ex...

Study on the Combination of Cefiderocol and Tetracycline Analogues for Treating Carbapenem-Resistant Acinetobacter baumannii Academic Background Carbapenem-resistant Acinetobacter baumannii (CR-AB) is one of the major pathogens responsible for hospital-acquired infections, often leading to severe conditions such as ventilator-associated pneumonia, ...

Discovery of Celludinone C and Its SOAT Inhibitory Activity Academic Background Sterol O-Acyltransferase (SOAT) is an enzyme that catalyzes the esterification of cholesterol and plays a critical role in maintaining intracellular lipid homeostasis. SOAT has two isozymes, SOAT1 and SOAT2, which exhibit significant differences in tissue distribution a...

Isolation and Identification of Three New Isomer Impurities in Milbemycin Oxime Drug Substance Academic Background Milbemycins are a class of 16-membered macrolides produced by Streptomyces, exhibiting potent anthelmintic and insecticidal activities with low mammalian toxicity. Milbemycins and their derivatives are widely used in agriculture and ve...

Structure-Activity Relationship Studies of ME1111—A Novel Antifungal Agent for Topical Treatment of Onychomycosis Background Onychomycosis is a globally prevalent disease affecting approximately 5.5% of the world’s population. Among its subtypes, distal-lateral subungual onychomycosis (DLSO) is the most common. The treatment of onychomycosis typica...

Advanced Bioresponsive Drug Delivery Systems for Diabetic Vascularized Bone Regeneration Background The treatment of bone defects in patients with Diabetes Mellitus (DM) remains a significant challenge, as the diabetic microenvironment severely impedes bone regeneration. Various abnormal factors in the diabetic microenvironment, such as hyperglycem...

The Impact of Inflammation on Brain Delivery of Oxycodone Academic Background Oxycodone is a widely used opioid analgesic with a unique property of being actively transported from the blood to the brain across the blood-brain barrier (BBB). This process is believed to be associated with the proton-coupled organic cation (H+/OC) antiporter system. H...

Tissue Factor Promotes TREX1 Protein Stability to Evade cGAS-STING Innate Immune Response in Pancreatic Ductal Adenocarcinoma Academic Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging malignancies worldwide, with increasing incidence and mortality rates, particularly in advanced stages. Despite significant prog...

Structure-Guided Development of Selective Caseinolytic Protease P Agonists as Antistaphylococcal Agents Academic Background Staphylococcus aureus is a common Gram-positive pathogen that can cause various human infections, including skin and soft tissue infections. With the widespread dissemination of methicillin-resistant Staphylococcus aureus (MRS...

Analysis of the Molecular Recognition and Signal Transduction Mechanism of PRRP and PRRPR Research Background Neuropeptides, as the most abundant signaling molecules in the nervous system, have over 100 identified types and play critical roles in processes like metabolism, pain sensation, and reproduction. Among them, RF-amide neuropeptides are cha...