An Explicit Estimated Baseline Model for Robust Estimation of Fluorophores Using Multiple-Wavelength Excitation Fluorescence Spectroscopy

Physics, Optics, Chemistry, Analytical Chemistry, Medicine, Medical Laboratory Science, Neurology, Neurosurgery, Medical Imaging, Oncology, Life Sciences, Bioengineering,
fluorescence spectroscopy   multiple-wavelength excitation   fluorophores   baseline model   non-linear optics   neuro-oncology   glioma  

Research Background Fluorescence spectroscopy is a widely used method for identifying and quantifying fluorescent substances (fluorophores). However, quantifying the fluorophores of interest becomes challenging when the material contains other fluorophores (baseline fluorophores), especially when the emission spectrum of the baseline is not well-de...

Tandem mass spectrum prediction for small molecules using graph transformers

Chemistry, Analytical Chemistry, Computational Chemistry, Information Science, Artificial Intelligence,
Mass spectrometry   Graph transformer   Small molecules   Fragmentation patterns   Prediction  

This is a paper about MassFormer, a graph transformer model for small molecule mass spectrometry prediction. This research addresses the problem of molecular identification in mass spectrometry data and proposes a novel deep learning approach to predict mass spectra of small molecules. Background: Mass spectrometry (MS) is an analytical technique w...

Assessing the contribution of the chemical exposome to neurodegenerative disease

Assessing the contribution of the chemical exposome to neurodegenerative disease

Chemistry, Analytical Chemistry, Environmental Chemistry, Medicine, Neurology, Life Sciences, Biochemistry, Immunology,
neurodegenerative diseases   exposome   chemicals   Alzheimer's disease   Parkinson's disease  

Assessing the Risks of Chemical Exposures for Neurodegenerative Diseases Introduction In recent years, many environmental chemicals, from solvents to pesticides, have been implicated in the development and progression of neurodegenerative diseases. However, a systematic approach akin to genome-wide association studies, which have identified dozens ...