Early-Onset Sleep Alterations Found in Patients with Amyotrophic Lateral Sclerosis Are Ameliorated by Orexin Antagonist in Mouse Models

Medicine, Neurology,
Amyotrophic Lateral Sclerosis   Sleep Alterations   Orexin Antagonist   Mouse Models   Neurodegenerative Diseases   Cognitive Function   Hypothalamic Signaling  

Mechanisms and Therapeutic Exploration of Early Sleep Abnormalities in Patients with Amyotrophic Lateral Sclerosis Academic Background Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by the degeneration of motor neurons, leading to progressive muscle weakness and respiratory failure. Although the primary symptoms ...

Homeostasis and Metabolism of Iron and Other Metal Ions in Neurodegenerative Diseases

Chemistry, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Biochemistry,
Neurodegenerative Diseases   Metal Ions   Iron   Manganese   Copper   Zinc   Chelators  

Homeostasis and Metabolism of Iron and Other Metal Ions in Neurodegenerative Diseases Academic Background Neurodegenerative diseases (such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and Huntington’s disease) are characterized by neuronal death and gradual loss of function, leading to the deterioration of cognitive, ...

miR206 and 423-3p are Differently Modulated in Fast and Slow-Progressing Amyotrophic Lateral Sclerosis Patients

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Biochemistry,
Amyotrophic Lateral Sclerosis   miRNA   Prognosis   Biomarkers   Neurodegenerative Diseases  

Differential Regulation of miR206 and miR423-3p in Rapidly and Slowly Progressing Amyotrophic Lateral Sclerosis Patients This article was published in the 2024 issue of “Neuromolecular Medicine,” titled “Differential Regulation of miR206 and 423-3p in Rapidly and Slowly Progressing Amyotrophic Lateral Sclerosis (ALS) Patients.” The authors include ...