Therapeutic Effects of Combination of Nebivolol and Donepezil: Targeting Multifactorial Mechanisms in ALS

Chemistry, Medicinal Chemistry, Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Amyotrophic Lateral Sclerosis   Neurodegeneration   Multifactorial Mechanisms   Drug Combination Therapy   Motor Neuron Protection  

Report on ALS Treatment Study: Exploring the Multifaceted Mechanisms of Nebivolol and Donepezil Background and Research Objectives Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive loss of motor neurons in the spinal cord and brain, leading to severe muscle atrophy, functional decline, and eventual death...

Genetic Associations with an Amyotrophic Lateral Sclerosis Reversal Phenotype

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Amyotrophic Lateral Sclerosis   Reversal Phenotype   Genome-Wide Association Study   Gene Expression   IGFBP7  

Genetic Association Study of ALS Reversal Phenotype Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the death of upper and lower motor neurons, progressive weakness, and eventual respiratory failure. However, individual ALS patients have exhibited unusual clinical reversal phenomena, where symptoms signific...

miR206 and 423-3p are Differently Modulated in Fast and Slow-Progressing Amyotrophic Lateral Sclerosis Patients

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Biochemistry,
Amyotrophic Lateral Sclerosis   miRNA   Prognosis   Biomarkers   Neurodegenerative Diseases  

Differential Regulation of miR206 and miR423-3p in Rapidly and Slowly Progressing Amyotrophic Lateral Sclerosis Patients This article was published in the 2024 issue of “Neuromolecular Medicine,” titled “Differential Regulation of miR206 and 423-3p in Rapidly and Slowly Progressing Amyotrophic Lateral Sclerosis (ALS) Patients.” The authors include ...

Comprehensive Assessment of TDP-43 Neuropathology Data in the National Alzheimer’s Coordinating Center Database

Medicine, Medical Laboratory Science, Geriatrics, Neurology,
TDP-43   Limbic Predominant Age-Related TDP-43 Encephalopathy Neuropathologic Change   Frontotemporal Lobar Degeneration   Amyotrophic Lateral Sclerosis   Hippocampal Sclerosis of Aging   Dementia   Alzheimer’s Disease  

Research Report Titled “Comprehensive Evaluation of TDP-43 Neuropathology Data in the National Alzheimer’s Coordinating Center Database” Research Background TDP-43 proteinopathy is a significant neuropathological feature in frontotemporal lobar degeneration (FTLD-TDP), amyotrophic lateral sclerosis (ALS-TDP), and age-related limbic TDP-43 encephalo...

Abundant Transcriptomic Alterations in the Human Cerebellum of Patients with a C9orf72 Repeat Expansion

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
C9orf72   Amyotrophic Lateral Sclerosis   Frontotemporal Lobar Degeneration   Transcriptomics   Cryptic Exons  

Research Background In the field of neuroscience, amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two highly heterogeneous neurodegenerative diseases. Studies indicate that non-coding hexanucleotide repeat expansions in the c9orf72 gene are the most common genetic causes of these diseases. However, the specific ...

The Cortical Neurophysiological Signature of Amyotrophic Lateral Sclerosis

Medicine, Neurology, Medical Imaging, Life Sciences, Immunology, Biophysics,
Amyotrophic Lateral Sclerosis   Motor Neuron Disease   GABAergic Interneuronal Circuits   Frequency Band Analysis   Electromagnetic Neuroimaging  

Analysis of Cortical Neurophysiological Characteristics of ALS and Its Potential as a Biomarker Background Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects adults, characterized by a gradual loss of the integrity of the brain, spinal cord, and peripheral motor system. Although clinical and genetic studies have reveale...