Genetic Association Study of ALS Reversal Phenotype Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the death of upper and lower motor neurons, progressive weakness, and eventual respiratory failure. However, individual ALS patients have exhibited unusual clinical reversal phenomena, where symptoms signific...

Differential Regulation of miR206 and miR423-3p in Rapidly and Slowly Progressing Amyotrophic Lateral Sclerosis Patients This article was published in the 2024 issue of “Neuromolecular Medicine,” titled “Differential Regulation of miR206 and 423-3p in Rapidly and Slowly Progressing Amyotrophic Lateral Sclerosis (ALS) Patients.” The authors include ...

Research Report Titled “Comprehensive Evaluation of TDP-43 Neuropathology Data in the National Alzheimer’s Coordinating Center Database” Research Background TDP-43 proteinopathy is a significant neuropathological feature in frontotemporal lobar degeneration (FTLD-TDP), amyotrophic lateral sclerosis (ALS-TDP), and age-related limbic TDP-43 encephalo...

Research Background In the field of neuroscience, amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two highly heterogeneous neurodegenerative diseases. Studies indicate that non-coding hexanucleotide repeat expansions in the c9orf72 gene are the most common genetic causes of these diseases. However, the specific ...

Analysis of Cortical Neurophysiological Characteristics of ALS and Its Potential as a Biomarker Background Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects adults, characterized by a gradual loss of the integrity of the brain, spinal cord, and peripheral motor system. Although clinical and genetic studies have reveale...