Early-Onset Sleep Alterations Found in Patients with Amyotrophic Lateral Sclerosis Are Ameliorated by Orexin Antagonist in Mouse Models

Medicine, Neurology,
Amyotrophic Lateral Sclerosis   Sleep Alterations   Orexin Antagonist   Mouse Models   Neurodegenerative Diseases   Cognitive Function   Hypothalamic Signaling  

Mechanisms and Therapeutic Exploration of Early Sleep Abnormalities in Patients with Amyotrophic Lateral Sclerosis Academic Background Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by the degeneration of motor neurons, leading to progressive muscle weakness and respiratory failure. Although the primary symptoms ...

Nanoligomers Targeting NF-κB and NLRP3 Reduce Neuroinflammation and Improve Cognitive Function with Aging and Tauopathy

Chemistry, Nanoscience, Medicine, Geriatrics, Neurology, Life Sciences, Bioengineering,
NF-κB   NLRP3   Neuroinflammation   Aging   Tauopathy   Cognitive Function  

Nanopolymer Targeting NF-κB and NLRP3 Reduces Neuroinflammation and Enhances Cognitive Function in Aging and Tauopathy Research Background Aging is a major risk factor for cognitive decline and most neurodegenerative diseases, such as Alzheimer’s disease (AD). These cognitive declines are closely related to the pathological aggregation of Tau prote...

GDF1 Ameliorates Cognitive Impairment Induced by Hearing Loss

Medicine, Geriatrics, Neurology, Life Sciences, Biochemistry,
GDF1   Cognitive Function   Hearing Loss   Alzheimer's Disease   Synaptic Function   Neurodegeneration  

Improvement of Cognitive Impairment Induced by Hearing Loss Background Alzheimer’s Disease (AD) is a common dementia characterized by extracellular amyloid plaques formed by aggregation of amyloid-β (Aβ) and intracellular neurofibrillary tangles formed by aggregated tau protein. Epidemiological studies indicate a close correlation between hearing l...