Aquaporin-4 Immunoglobulin G–Seropositive Neuromyelitis Optica Spectrum Disorder MRI Characteristics: Data Analysis from the International Real-World PAMRINO Study Cohort

Medicine, Neurology, Medical Imaging,
Neuromyelitis Optica Spectrum Disorder   Aquaporin-4   MRI Characteristics   International Study   Central Nervous System Lesions  

Research Background Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune central nervous system disease characterized by severe onset and relapse events, including optic neuritis, longitudinally extensive transverse myelitis (LETM), brainstem and/or hypothalamic syndromes, and encephalitis. Most patients have serum immunoglobulin G (IgG)...

Serum LDL Promotes Microglial Activation and Exacerbates Demyelinating Injury in Neuromyelitis Optica Spectrum Disorder

Medicine, Infectious Diseases, Rheumatology and Immunology, Neurology, Life Sciences, Cell Biology,
Neuromyelitis Optica Spectrum Disorder   Low-Density Lipoprotein   Microglia   Blood-Brain Barrier   Lipid Metabolism   Glycolysis   Demyelinating Injury  

Study on Serum LDL Promoting Microglial Activation and Exacerbating Demyelination in Neuromyelitis Optica Spectrum Disorder Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS), often accompanied by disruption of the blood-brain barrier (BBB). Dysfunction of lipid met...