Serum LDL Promotes Microglial Activation and Exacerbates Demyelinating Injury in Neuromyelitis Optica Spectrum Disorder

Medicine, Infectious Diseases, Rheumatology and Immunology, Neurology, Life Sciences, Cell Biology,
Neuromyelitis Optica Spectrum Disorder   Low-Density Lipoprotein   Microglia   Blood-Brain Barrier   Lipid Metabolism   Glycolysis   Demyelinating Injury  

Study on Serum LDL Promoting Microglial Activation and Exacerbating Demyelination in Neuromyelitis Optica Spectrum Disorder Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS), often accompanied by disruption of the blood-brain barrier (BBB). Dysfunction of lipid met...

Comparison of Sonication Patterns and Microbubble Administration Strategies for Focused Ultrasound-Mediated Large-Volume Drug Delivery

Medicine, Medical Laboratory Science, Neurology, Oncology, Life Sciences, Bioengineering, Immunology,
Focused Ultrasound   Microbubbles   Large-Volume Drug Delivery   Blood-Brain Barrier   Immune Checkpoint Inhibitor  

Comparison of Acoustic Patterns and Microbubble Delivery Strategies in Large-Volume Drug Delivery Mediated by Focused Ultrasound for Blood-Brain Barrier Opening Background Diffuse Intrinsic Pontine Glioma (DIPG) is the most common and lethal brainstem tumor in children. Due to the usually intact blood-brain barrier (BBB) in DIPG, drug penetration i...